Cameron Jerome became Norwich's firth signing of the 2014 summer when he joined the Canaries from Stoke City on 20th August 2014 for a fee reported to be £2m.

Jerome was born in Huddersfield, West Yorkshire. As a youth, Jerome played for Stile Common, Yorkshire Counties and Westend Juniors before moving on to Huddersfield Town as a junior, then moved on via Grimsby Town, Sheffield Wednesday and Middlesbrough to gain a contract at Cardiff City, after being recommended by reserve team manager Paul Wilkinson Jerome played under Wilkinson in Grimsby's youth system, but after Wilkinson left Blundell Park to take up his position with Cardiff in October 2003, Jerome was released by replacement Neil Woods for being a disruptive influence.

Jerome made his Cardif City debut in a 0–0 draw with Leeds United on 2nd October 2004, as a substitute for Andy Campbell, before going on to score seven goals in 32 appearances in the 2004–05 season.,A good run of form in the 2005–06 season saw him finish top scorer for Cardiff with 20 goals.

He signed for Birmingham City on 31st May 2006, for a transfer fee reported as an initial £3 million, potentially rising to £4m.] Jerome made his debut as a 66th-minute substitute against Colchester United at St Andrew's on 5th August 2006. However, it was a debut to forget, as he was sent off within five minutes of entering play elbowing an opponent in the face. He netted his first goal for Birmingham against Queens Park Rangers at Loftus Road on 12th September but had a slow first season at St Andrew's, scoring just 9 times in 44 games in all competitions.

Jerome scored his first Premier League goal after 32 seconds of the away match against Derby County on 25 August 2007; his second goal of that game confirmed Birmingham's first win of the 2007–08 season. He finished the season as Birmingham's second top goal scorer with 7 goals in 33 games as Birmingham were relegated. However, the Blues immediately bounced back in the 2008–09 season by finishing second in the Championship with Jerome scoring 10 goals in 45 appearances. He won the League Cup with Birmingham in 2011.

He scored 11 goals in the 2010-11 season winning him a £4million transfer to Stoke City on 31st August 2011. He scored on his Stoke City debut in the UEFA Europa League against Dynamo Kiev to earn his side a 1–1 draw away from home.

On 5th August 2013 Jerome admitted an FA charge of breaching betting regulations. He was fined £50,000 and was also severely warned as to his future conduct by the FA.

On 2nd September 2013 Jerome joined Crystal Palace on loan for the 2013–14 season. He made his debut for the club on 14th September 2013, coming on as a 64th-minute substitute for Dwight Gayle in a 2–0 defeat away at Manchester United. In total Jerome played 29 times for the Eagles scoring twice as they finished in 11th position.

At the time of joining Norwich, he had played 67 games for Stoke, scoring 12 goals.

Jerome made his debut for Norwich in the Capital One Cup victory at home to Crawley Town on 26th September 2014, scoring one of the goals in a 3-1 win.

He made 45 appearances in 2014/15 scoring 21 goals including the opener in the 2-0 Championship Play-off final against Middlesbrough on 25th May 2015. This was his 21st goal of the season and the first goal scored by a Norwich player at Wembley (unless you count Asa Hartford's defected shot in the 1985 Milk Cup final)..

Jerome made 34 appearances for City in 2015/16, scoring three goals, as the Canaries were relegated from the Premier League.

He signed a new three year contract with Norwich on 13th June 2016 even though he had been linked with a move to Middlesbrough. He scored 16 goals in 40 games in 2016/17.

On 11th June 2017, it was reported that Norwich would listen to offers from Jerome as they sought to bring in transfer revenue and reduce the wage bill. Middlesbrough and Sunderland were reported to be interested.

On 28th December 2017, it was reported by the Mirror that Cardiff were keen to re-sign Jerome to strengthen their attacking options following injury to Danny Ward. A fee of £1.5million was mentioned. On 1st January, Derby, Sunderland and Birmingham were added to the list of suitors. He moved to Derby on 16th January 2018 on an 18 month contract with Derby paying an undisclosed fee said to be £1.5million.

On 31st August 2018, Cameron turned down overtures from Ipswich to join Turkish top flight side Goztepe. He had made just 4 appearances for the Rams, scoring once.

Jerome was released by Goztepe in the summer of 2020 and was linked in October 2020 with a reunion with former Norwich teammate Russell Martin now managing MK Dons. According to Football Insider’s transfer expert Pete O’Rourke, Jerome is set to put pen-to-paper to sign a one-year deal with the Dons. This was confirmed on 9th October 2020 with Martin saying "He really buys into everything we are doing and he's going to be a really good signing for us."

Jerome scored 15 goals in 39 games in all competitions and was a regular starter as Martin's side secured mid-table safety in League One  The 34-year-old had only signed a one-year deal though and has opted on 18th June 2021 to take the opportunity of Championship football with Luton Town, with the Hatters announcing he will join as a free agent on 1st July 2021. Luton boss Nathan Jones said “It’s really interesting one actually because Cameron ticks so many boxes for us. We wanted someone specific because we’ve only got one target man really, and that’s Elijah Adebayo. So we wanted to bring in another target man, one for competition for Elijah, but also to provide something a little bit different as well. We feel Cameron can do a bit of everything, so it’s a real logical one. The experience he brings is one thing. We felt that coming back from abroad, when he went to MK and had to re-prove himself, we felt he did that really well. We’ve looked at so many front men now, and we felt that what he would give us, he’s the best about."

Agreeing to end his Hatters contract by mutual consent on 27th January 2023, he then signed an eighteen month contract with Bolton the same day. Bolton boss Ian Evatt said "He's played at the top level, in Europe and played 50-odd times in the Championship in the last two years. People shouldn't be mis-guided by his age. His physical data is still unbelievable and he's in incredible shape. We're signing him because we think he can have an affect on the team and help us."

After Bolton failed to secure promotion to the Championship, losing to Josh Murphy's Oxford at Wembley on 19th May 2024, Bolton announced that Jerome was one of three senior players to depart Bolton. He had scored four goals in 55 appearances.

Jerome made 10 appearances for the England under-21 team between 2005 and 2007 but failed to score.