Anthony Spyrou, from Norwich's Under-16 squad, made his debut as a late substitute for Norwich's Under-18s in a 3-1 win over Brighton on 3rd October 2015. He scored City's third goal with his second touch of the ball.

He was one of ten yougnsters to join Norwich's Under-18s as first year scholars on 1st July 2016.

On 30th June 2018, he signed his first professional contract with Norwich

He signed a new one year deal with City on 20th February 2019. On 19th March 2019, he was loaned to Wrexham on a youth loan until the end of the 2018/19 season after scoring seven goals in 15 Premier League 2 games for the Under-23s. He made his Wrexham debut on 23rd March 2019 in a 1-0 defeat to Hartlepool in the National League. He made three appearances in total for Wrexham.

Spyrou then trialled with National League side Chesterfield in July 2019, playing and scoring in a 2-1 win over Matlock on 16th July and against Hallam FC. A season-long loan with the Spireites was confirmed on 23rd July 2019. Spyrou becomes the 10th Norwich player out on loan for the 2019/20 season. He returned to Norwich in mid-November ending the loan short after just five appearances.

On 17th December 2019, his contract was cancelled by mutual consent

He returned to his native Essex and joined Holland FC who play in Thurlow Nunn Eastern Counties First Division South, at step six of non-league, the equivalent level to Norfolk clubs including Diss, Great Yarmouth and Fakenham. Holland boss, Paul Phelan, said: "To be truthful, he should be playing at a much higher level, in front of big crowds. But things haven't worked out for him in the pro game and, to his great credit, he just wants to be happy. He's been homesick and hasn't enjoyed living far away, in hotels and flats. He wants to be back in the area, near his parents and girlfriend, and I admire him for being so honest. People will suggest he's unambitious but he's just a really decent, grounded lad who wants to be happy. He wants to be near his family and there's nothing big-time about him. After being in the pro game, he could have looked down his nose at non-league football but nothing could be further from the truth. To say I'm over the moon that's he's agreed to join us is an understatement."

On 11th May 2021 it was reported that he had signed for Stowmarket who play in the Thurlow Nunn Eastern Counties Premier Division.

On 23rd September 2023 he moved to Wivenhoe Town who play in the Thurlow Nunn Eastern Counties League First Division North.