Manchester United youngster Michael Twiss played in Norwich City Reserves' 2-0 victory over Oxford United on 21st February 2000. A friend of Philip Mulryne, Twiss was to be released from Old Trafford in the summer of 2000. Mulryne advised him to consider joining the Canaries. "I grew up with him. We did our apprenticeships together and now he has found himself in the same situation I did - playing in midfield and finding he cannot get near the first team" said Mulryne. "A lot of them will be leaving over the next couple of years because they are getting frustrated and are looking for first team football. Norwich would be a good move for Michael, and I will be trying to persuade him to come". Twiss had made only 2 first team starts for United but played 17 times in a loan spell with Sheffield United last season.

Despite scoring in his second reserve team trial (at Wycombe), Bruce Rioch decided not to take "any further action at this moment in time" on signing Twiss who apparently returned to Manchester.

On 9th March 2000, Teamtalk reported that Michael had gone on trial to Preston North End, even though they have a number of left sided midfielders (David Eyres, Paul McKenna). If he did move to Deepdale, he would follow Jonathan Macken, Michael Appleton and Colin Murdock as former Man United youngsters who had joined Preston. The Sun reported on 17th March 2000 that Michael was now having a trial with Norwich's First Division rivals Tranmere. Twiss however was not taken on because he wanted assurances about his future which Tranmere were unwilling to give without further observation. The Football Transfers website reported on 18th April 2000 that Michael had been linked with Scottish side St Johnstone. Michael was officially released by United on 19th June 2000.

Michael joined Port Vale on trial on 5th July 2000. Playing in the 2-0 victory over Leek Town, Vale boss Brian Horton was impressed; "he looked good on the ball and was good going forward". He impressed so much that Vale signed him on a one month contract starting 25th July so that they could evaluate him fully. This was made permanent but Port Vale's embarrassing FA Cup 1st Round exit to Rymans Leaguers Canvey Island saw Michael and three other Vale players transfer listed for their lack of commitment. On 8th April 2001, a number of papers reported that Twiss was one of five players that Wolves boss David Jones was hoping to bring to Molineaux in the summer. A fee of £500,000 was mentioned. Chesterfield were said to be keen on Twiss' signature.

Twiss joined Leigh RMI in the Football Conference for the 2001/02 season where he was a first team regular. In mid May 2002, he transferred to Conference rivals Chester City although Third Division York and fellow Conference side Doncaster both showed an interest. After a successful season with Chester where they reached the Conference play-offs, it was said that Third Division Leyton Orient were preparing a bid to enable Michael to return to league football.

Twiss fell out of favour with Chester manager Mark Wright in the autumn of 2003. In January 2004, he hadn't played since the previous October. Morecambe made a bid of £5000 which Chester were thought to be considering especially as it would clear Twiss' wages off the payroll. In the end, Twiss re-established himself in the Chester squad that won the Conference title in April 2004 and thus promotion into the Football League. Offered a new contract, he rejected it and instead signed for Morecambe at the end of April 2004.

In February 2005, Morecambe rejected a £50,000 bid from Coca-Cola League Two side Chester City for Twiss. Morecambe manager Jim Harvey was delighted that the board had rejected the offer. He said: "Michael has done well for us this season, his football and confidence are improving all the time and I feel he will play a pivotal role in our assault for a play-off place in the Nationwide Conference. I spoke with Michael this morning and he made it very clear to me that he did not want to move from Morecambe.

Twiss himself said: "I am very happy at Christie Park and enjoying my football more now than I have for quite some time. We have a great set of lads and the atmosphere and team spirit at the club is superb,we are in a good position to be in the play-offs and I am certainly not looking for a move from here at all."

In August 2008, Michael was linked with a move to Bury whose manager Alan Knill had enquired after him

Released by Morecambe in March 2010, Twiss signed for Stalybridge Celtic on 8th March 2010. He made 202 appearances for the Shrimpers, scoring fifty-three goals. He links up again with Celtic boss Jim Harvey, who managed him at Christie Park.

In May 2010, Micheal signed for Altrincham.